Ventral striatal activation during reward differs between major depression with and without impaired mood reactivity

Recent efforts to classify subtypes of major depressive disorder marked by different psychophysiological indicators have identified blunted reward-related brain activation in gambling tasks as a characteristic linked specifically depressed participants with impaired mood reactivity. The current study compared individuals diagnosed (n = 26) healthy controls 24) regarding responses gain and loss trials an fMRI version the “Doors” choice-feedback task. Study aims were examine relation depression, subtypes, course depression. Across sample, showed significant response versus left right ventral striatum well medial lateral prefrontal cortex. Relative controls, depression characterized reactivity striatum. Furthermore, differentiated subgroups without Finally, striatal hypoactivation reward predicted remission when controlling for symptomatology, albeit at trend level. Blunted might be useful marker subtype may potential predict future